THEORY OF THE EPIZOOTIC PROCESSMain laws and categories in epizootic processGrounds for necessity of theoretical developments in epizootology Epizootology is an ancient science. It was raised due to the needs of people to prevent animal herds. During centuries scientists described directly observable epizootic events. There were attempt to explain them and to work out methods to control infectious diseases. The evolution of theories in epizootology proceeded to changes of views on causation in epidemiology. The thorough work by Y.D.Belyakov (1964) reveals this problem in details. Long before discoveries in microbiology epizootologists analyzing observable events correctly interpreted the reasons of diseases’ propagation and worked out the preventive and antiepizootic measures. In this connection N.Ph.Gamaliya (1939) wrote “... observational epidemiology succeeded on its own – without help of microbiology and experiments – not only to determine the most important natural conformities of epidemics but also to find the reliable agents to control them. In the eighties of the X1X censure the science of contagiousness helped is”. Since this period the theory of contagiousness received a quite microbiological interpretation. Results of numerous observations and experiments were already explained in terms of the microbe theory of contagiousness of infections diseases (foot-and-mouth disease, brucellosis, tuberculosis, glanders, hog cholera, etc.) is raised with dispersion by infected animals of specific contagious. Due to this peculiarity a disease is propagated by means of direct or indirect contact between infected and uninfected animals. It was found, that in those cases when a disease appeared without such contacts its contagious lived in the soil (siberian plague, emphysematous carbuncle, tetanus) or penetrated organism of domestic animals through wild carnivores (rabies), rodents (listeriosis), Aujeski’s disease) and other sources. Based on these observations and experiments the microbe theory of contagiousness became the main leading principle for epizootologist. Classic epizootology recommends conception which can be manifested as the following: all the infectious diseases are caused by specific contagions propagating through immediate contagion or indirectly through causative agents. According to the theory of contagiousness of preventive and antiepizootic measures are formulated. Those ideas were so useful both for practice and for veterinary science. The practical measures arising from the microbe theory of contagiousness is following: isolation of sick animals, disinfection of environment, preventive and antepizootic quarantine for animals and determination of specific contagium. Scientific observations aim finding means to diagnose a disease and to prevent it in order to create insusceptibility of animals, scientifically grounded understanding of nature of infectious diseases, etc. The main principles of the theory of contagiousness and the facts on which it was created are undoubtedly objective reality and their truth does not give rise to doubt. The studies in terms of this theory will be continued in the nature. During resent decades many facts have been gathered which cannot be interpretated with the theory of contagiousness. There are also facts conflicting with the theory of contagiousness. Therefore further deep theoretical developments are required. Together with it “with respect to science the theoretical development of epidemiology and the development of new effective methods to prevent infectious diseases are behind most of all” (П.Н.Бургасов, И.С.Безденежных, 1977). It concerns epizootology in particular. We’ll give a few examples showing the contradiction and the lack of agreement between facts concerning propagation of infectious diseases of animals and the theory of contagiousness in that form in which it is interpreted by the current epizootology. The socialist system and the social property of production created favorable conditions for development of animal husbandry however the preventive measures based on the principles of contagiousness are not successful. Their implementation during decades reduced sickness rate bat it did not lead to any improvement of the health of animals. Some diseases continue to propagate at high rate (brucellosis, tuberculosis) and others ones, even after obvious improvement (foot-and-mouth disease) appear again causing harm to the national economy. Now there are diseases which have not been recorded up to date (paragrippe-3, rinotracheitis, rota- and coronavirus infection of calf, poliserositis and transmissible gastroenteritis of pigs, chlamydiosis, mycoplasmosis, etc.). And such diseases as equine anemia and number of others practically disappeared without any preventive measures and diagnostics. The high level of preventive measures against such diseases as Siberian plague (anthrax), hog erysipelas and a number of others, of course, made it possible to reduce both a number of outbreaks and sickness rate at the modern stock – breeding farms. Bat these measures do not ensure sufficient conditions concerning health of animals. Theoretical views do not explain such things their fore many people try to blame the veterinary surgeons for their bad work. We can give the examples contradicting the existing theoretical conceptions of contagiousness based on certain diseases. For example, in the course of many experiments they can’t manage to infect animals with anthrax through oral way but all the save the infection is regarded as an oral one. It is considered that those animals that have injured mucous membrane of their oral cavity are exposed to an infection. Bat a trauma is an accidental phenomenon which can’t form the objective regularities to be characteristic of our modern situation. If contaminated with anthrax’s causative agent fodder or soil distinguished the modern epizootic situation in combination with an animal’s injured mucous membrane of the oral cavity then the disease should be found more often among sheep since they often swallow their fodder together with soil and lice to tat coarse dry stalks. Bat it is not observed, the outbreaks of anthrax owing to the disease of cattle are more than two third of all the outbreaks. If said factors determined the epizootic situation anthrax would be registered in early spring or late autumn when there are scantly haulage and a great amount of dry coarse plants on the pastures. The outbreaks continue to be registered principally in July-August just as during the pre-vaccinal period when the pasture’s conditions are less favourable for the trauma of mucous membrane within the oral cavity. Every year from May to October the number of anthrax among small-size cattle is 93±2%, among cattle is 78±3% of all the outbreaks for a year. Such distinct objective regularities cannot be generated by such accidental event as a trauma of the oral cavity is. The theory of contagiousness connects outbreaks of anthrax with a long-term keeping of the causative agent in the soil (it is a well-established fact), therefore the cause of outbreaks is assumed to be the places where deed bodies were buried. But almost a half of anthrax’s outbreaks occur in the areas where the disease has not been registered for more then 50-100 years (Б.Л.Черкасский, 1979). In the past there was a mass propagation of the disease within the areas now it is not observed even if the level of vaccination is not high. This fact is in contradiction with the theory of contagiousness. In other areas the disease is often registered in presence of the 100% annual vaccination. Having faced the contradiction between the opinion way and factors to transmit anthrax’s causative agent and the facts (the objective regularities of disease propagation, the experiments to infect using oral way, the absence of mass trauma of oral cavity in natural conditions, the disparity between a probability to injure the different of farm animals and the propagation of anthrax among them and so on), using the methods of theory of probability we tried to determine the significance of soil contaminated with a causative agent and the animals having injured mucous membrane of their oral cavity in propagate. We used the theorem of multiplication of probability independent events. The terms of the task were determined on the basis of the known experiments and the data epizootic investigations. In many cases we found then the outbreaks had happened among the vaccinated animals. It was possible because of the animals missed during the vaccination or because of other factors. We assume that no more than 10% of such animals can be within a herd. The trauma of the mucous membrane of the oral cavity can be assumed to be not more 10% of animals. It is necessary to take into consideration that only 33% of non-immune animals with the oral cavity injured mucous membrane developed disease during the experiment conducted by L. Paster (1960). We assume that a herd consisting of 150 cows grazes on the pasture 100 ha (1 mln. m2 ) every day for 6 months (180 days). This pasture has 4 contaminated with anthrax’s causative agent limited plots. In our case the first independent event is the fact that only 10% of non-vaccinated animals can develop the disease (15 cows). The probability of this event is P (A) = 15: 150 = 0,1. The second independent event is the probability of disease only for 10% of cows (15 cows) having injured mucous membrane of their oral cavity. The probability of this event is P (B) = 15: 150 = 0,1. The third independent event is the fact that 33% of the animals with injured mucous membrane of their oral cavity can develop the disease (5 cows). P(C) = 5: 15 = 0,33. The fourth independent event is the fact that the animals can be infected only within 4 plots. The area of said plot is no more then 1 m2 . P (D) = 4: 1000000 = 0,000004. The probability of joint appearance of said independent events for one day the product of these events probabilities.^ P (A·B·C·D) = P (A) · P (B) · P (C) · P (D) P (A·B·C·D) = 0,1 · 0,1 · 0,33 · 0,000004 = 0,0000000132. Taking into consideration that the animals can cross the same plot twice, and they are grazing for 180 days, then received probability should be multiplied by 360. 0, 0000000132 · 360 = 0,000004752 Such is the probability of anthrax’s outbreak within a herd of 150 cows where 10% of animals are non-immune, - 10% of animals have traumas of their oral cavity mucous membrane and are grazing on the pasture of 100 ha where there are 4 limited plots contaminated with anthrax causative agent. In order to realize this probability it’s necessary the 200000 years (1: 0,000004752 = 210437, 7). Therefore if the modern epizootic situation had been determined by the fact of anthrax’s causative agent survival in soil and its transmission to the animals with injured mucous membrane of their oral cavity together with fodder or soil then the outbreaks should not have already been observed. But still the epizootic process of anthrax is being continued. We are compelled to draw a conclusion that in modern situation there some unknown ways to transmit anthrax’s causative agent. These ways cannot be explained using the traditional theoretical views of the epizootic process. The theory of contagiousness does not explain appearance of mass gasbointestinae diseases and viral respiratory diseases of young cattle living in specialized large cattle-breeding complexes though they were not registered by the traditional farms. There are many such examples. On the basis of the theory of contagiousness it is not possible to determine where, when, of what volume and how long the specific preventive measures against the majority of infectious diseases should be conducted. We can say that in modern situations there are quite a lot of facts on the basis of which it is possible to extend the theoretical elaboration of epizootology. Now animals are concentrated at the specialized farms so the veterinaries ought to have the knowledge both of treatment of the diseases and theoretical basics of epizooty. It is stipulated by the fact that the veterinaries have to resolve more and more complicated problems to develop stock-breeding. These problems were not typical of the extensive way of farming. The role of theoretical knowledge is the most important for livestock farming. To direct some preventive and antiepizootic measures without the knowledge of epizootic process’ rules becomes impossible. This principle coordinates with the conception of materialist dialectical methodology of scientific cognition and the demands of scientific and technological revolution. Because of the facts concerning the peculiarities of infectious disease propagation are established and the existing theoretical conceptions not explain them, even sometimes contradict them a new interpretation of those facts is required. Therefore it is necessary to recompreherd the facts, to represent in a new way the data concerning the infectious diseases propagation during some long period taking into consideration the active influence of preventive measures over their propagation, to work out the additional theoretical principles in agreement with the peculiarities of some typical infectious diseases’ propagation, to interpret the appearance and the propagation of new infectious diseases. The new theoretical principles ought to contribute to more effective control over the propagation of diseases. In connection with the fact that the principal idea of contagiousness is established and well-grounded it is not necessary to interpret it somehow. The only thing left is to expound the separate essential principles corroborating each of them with some practical observations. We regard the theory of contagiousness as a basis giving the definition of some essential principles which are considered to be the laws of epizootic process. We precede the fact that “law essence is the homogenous notions”. The structure of this theory presents the dialectical unity of the said laws. The theory of such kind be applied for understanding factors having influence on the appearance of so-called “new” diseases, their characters and peculiarities concerning the prognosis of an epizootic situation. The attempt to differentiate the theory of contagiousness into separate essential principles (the laws of epizootic process) is proved to be correct since a complicated biological phenomenon as the epizootic process, in our opinion, is developing according to several laws; each of them is an essential connection of the said process. The main principles of materialist dialectics should be the methodological approach to unfolding of epizootic process’ laws. The epizootic process should be unfolded through unity of dialectical categories of necessity and chance, cause and effect, possibility and reality, external and internal, necessity and purposefulness. Of source, the epizootic process’ laws should stand on a sound base of detailed analysis of the facts including both the manifestation of epizootic process and the experimental results. It is the manifestation of epizootic process, its laws (no regularity bat nature’s laws) and results of the experiments are the external visible aspect of epizootic process. The scientific explanation of epizootic process’ objective development, the experiments and the observations form the system of leading ideas being an internal essential aspect of epizootic process and the said system is regarded as the theory of epizootic process. Therefore the dialectical unification of epizootic process’ laws to form a scientific theory should be the basis to discover causes and ways to propagate the specific infectious diseases and to forecast their outbreaks. “Any scientific theory serves as foundation for further knowledge of given subject” (И.Д.Андреев, 1972). The theory of epizootic process should unify all the essential connections of the said process (formulated as laws) owing to which it exists. This theory should supplement the existing conceptions of contagiousness, concretize their main principles, explain all the cases known to the modern veterinary science and the peculiarities of propagation both of traditional for stock-breeding and newly showed up infectious diseases. Such a theory is founded on the principles of contagiousness and the profound knowledge of biology that is the theory of evolution, the law of biogenetics and so on. It is a basis for works on control of the infectious diseases in the very near years. Some practical results of the epizootic process’ theory will be interpreted with the help of veterinary hygiene, sanitation, the system of general and specific preventive and medicinal measures.Parasite - host nature of the epizootic process So as to determine the general epizootic process in terms of the theory it is necessary to distinguish the essence of some simulated (model) epizootic processes. Therefore we did not confineourserves to the epizootic model of one or several infectious diseases. We took into consideration the data of our and foreign countries’ literature concerning the propagation of different infectious diseases and the theory of epizootic and epidemic processes, also the results of long epizootic observations and examinations of the outbreaks of anthrax, rabies, foot-and-mouth disease, tuberculosis, brucellosis, leptospirosis, listeriosis of farm animals, hog cholera and hog erysipelas, viral respiratory diseases of young cattle and others infectious diseases. Working out the theory of epizootic process using the epizootic model of said infectious diseases we based ourselves ob the universal laws, categories and notions of materialist dialectics. At fist sight derived through logic theoretical principles concerning the epizootic process of concrete infectious diseases. But the deeper and detailed interpretation of the theory using the modes of epizootic process of the said infectious diseases confirms its regularity and high informative ness. Without a doubt that the cause of concrete infectious diseases is specific causative agent: bacteria, viruses and so on. They are called parasites by modern science. Thinking out the peculiarities and regularities to manifest the epizootic process of farm animal different diseases and also taking into consideration the data of publications concerning this subject (В.Д.Беляков, 1964; Л.В.Громашевский, 1962; И.И.Ёлкин, 1960; М.И.Верещагин, 1962) it is possible to regard the law of parasite and host relations to be the principal law of epizootic process. Its main point consists in the fact that all the causative agents of infectious diseases are parasites and their predominant living environment is the organism of host. The epizootic process is characterized by parasite and host relation between the populations of some causative agent and the populations of susceptible animals. In aggregate they represent a dynamic system with intermittent balances. This law is obligatory for the epizootic process of all infectious diseases. It is convincingly confirmed by many facts and its objectivity is pointed out by a lot of scientists. Since the causative agents of infectious diseases are parasites their living environment will be human or animal organisms. Some apparent exceptions only confirm this rule. Soil even to a considerable extent polluted with anthrax bacilli is purified of them as they die out (В.М.Жданов, 1965). The greatest achievement of modern science is acknowledgement that the parasitic nature of causative agent assumes not only its parasitism in a new organism, infected just now but also the fact that the parasite came here after parasitic state within another organism as well (Л.В.Громашевский, 1962). In M.N.Vereschagin (1962), the development of infectious diseases is the objective manifestation of parasitism acting in nature. The causative agents of infectious diseases are regarded as parasites (И.И.Ёлкин, 1960; И.В.Давыдовский, 1956; П.И.Притулин, 1969; В.Д.Беляков, 1975) etc.Obligate ness of animal species for causative agents Animal organisms of different species are not equivalent environments for the vital activity of parasites being the causative agent of infectious diseases. Only certain animal species can be a predominant environment for the vital activity of certain parasites. In the process of evolution the state of biological balance being characterized by latent going through disease or the state of “carrying” established between them and the parasites. Of course the biological balance between the parasite and its host should be regarded relatively as a universal biological conception characterizing their relations. This balance can be essentially violated under the effect of environment leading to the changes in parasite’s living conditions. In this interpretation the balance should be joint evolution of interspecific relations between the host and its parasite are studied by ecology of associations or biocenology (Н.П.Наумов, 1963). Such a balance can established in that case when in the process of evolution the biocenotic connections allowed the parasite to penetrate the animals of only a certain species. The generations of parasites changing each other were in the same living conditions. This peculiarity is considered to be one of the principal characteristics of parasitism. In V.A.Dogel’s opinion (1962), “parasites are adapted only to a certain environment that is to a certain animal species being the host pr group of species”. All this determined the specificity of environment for the causative agents’ living. “The specificity can be interpreted as the adaptation of parasites to a certain king of species or group of species (living conditions), what manifests itself through the coincidence of the parasite with its host. The parasite is adapted to its host and vice versa. The specifiticity can be defined as the norm of environment response. It is an ecologically stipulated phenomenon” (И.А.Догель, 1962). Regarding the majority of pathogenic for animals viruses (Я.Р.Коваленко, 1973; 1975), helminthes (И.А.Рубцов, 1940; Р.С.Шульц, 1955), the scientists came to the said conclusion. The questions of parasite-host specificity are not only an ecologic problem considering the question for the point of view of living conditions and development of the parasite and its host, bat also an immunologic problem aiming at the study of both partners’ immunologic processes (Р.С.Шульц, 1955). Analyzing the appropriate facts the authors assume that in the process of long joint evolution of the parasite and its host some definite relations are created within the obligate system. Those relations make it possible to compensate to some extent the pathological process of the obligate host. But the authors are not agree with the theory (Ш.Николь, 1937) concerning dying of parasite’s pathogenicity away with phylogenetic age parasite-host system. They furnish no evidence. The work of V.D.Belyacov considers in detail the question of latent going though disease or “carrying”, which became possible owing to the fact that in the process of evolution the organism of certain animal species has been determined as the principal internal environment for the vital activity of certain parasites. The animals of other species are not internal environments for such parasite as a certain type. They did not adapt to the parasite existence within them and having faced it go through disease painfully. The organism of third animal species is not a suitable environment for certain parasite’s vital activity at all. The conclusions concerning the obligate ness of certain species animal’s organism for a certain type of parasite being the causative agent are confirmed with a great deal of epizootic observations. For example, horses have glanders disease (mallens) mainly in a chronic form. 87% of all the horses having glanders in the USSR during 1925-1926 were the animals with chronic latent forms of grander disease (mallens). This horses not having the clinical symptoms of the disease (С.Н.Вышелесский, 1948). They were reacting only to mallein. And carnivores have the acute and super acute forms, as a rule, with lethal outcome. Cattle do not develop glanders even during massive infections. Then different animal species’ organisms unequally respond to the penetration of one and the same disease causative agent. If this peculiarity is considered to be the evolutionally established necessity for the causative agent to penetrate such animals, the organism of which is determined to be the optimal internal environment for the given parasite that said peculiarity us considered from the position of availability 0f evolutionally established biocenotic connections the role of mechanism of transmission of the causative agent then it is easy to understand that cattle’s organism is an unsuitable environment for the vital activity of glander’s causative agent. And the carnivore organisms is, undoubtedly’ a suitable environment. But it is not these animals that determine the survival possibility for the parasite. Such a conclusion is confirmed by the epizootic data, analysis of which makes it possible to affirm that carnivores do not propagate this disease causative agent, on the contrary’ they are the biological impasse for it. Carnivores, principally, are infected by horses. At the same time the causative agent of glanders successfully survives in horse organism having a chronic form of this disease or the organism of horses us only the “carrier” of causative agent without displaying clinical symptoms and even without some pathological and anatomical changes (С.Н.Вышелесский, 1940). It is apparent that in the process of evolution such bioctnotic connections were established that glanders causative agent naturally penetrate the organism of horse. The adaptation of parasite to a certain environment was going on. And horses, in their turn, in the course of such relations evolution developed the tolerance towards its vital activity. The state of biological balance providing the parasite with the opportunity to survive as a species was established. The relations between the virus of African hog cholera and aboriginal hogs were established analogically. It was showed (Я.Р.Коваленко, 1973) that the biological balance was established between them therefore the virus being in cells of their lymphatic system does not cause pathological changes in normal conditions. The cattle’s organism is specific for the causative agent for cattle brucellosis. The state biological balance became established between the host and parasite. Though some other animal species can be also infected with Bovine brucellosis but it is obvious that the causative agent of Bovine brucellosis can survive as a species only in cattle organism. The horse organism is specific for the causative agent of equine anemia. The bird organism is specific for the causative agent of avian tuberculosis. Naturally, the cattle organism is specific for Bovine tuberculosis. In many cases Bovine tuberculosis is connected with the bad conditions of farm in the past (А.И.Кузин, 1977). The disease appeared without bringing of the causative agent from outside in 14 of examined farms. According to the author the principal cause of such outbreaks is the latent carrying of causative agent. With the help of the pathologic material of 170 animals having positive reaction to tuberculin without any visible pathomorphological changes it was found the availability of the causative agent of tuberculosis among 84 samples using biological test. This fact confirms the presence of latent infection. The epizootic analysis of 91 herds material in the South of Ukraine showed that the reappearance of tuberculosis is registered in one year in 14,3% of cases, in two years – 40,4%, in three years – 22%, in five years – 5,5% and in six years – 2,2% of cases (С.И.Кованда, 1977). Within the herds made healthier after long terms of troubles there are always microbe carriers being clinically heal thy animals, but dangerous enough for further propagation of the disease (Н.А.Александров, 1978). It is possible that tuberculosis exists in latent form in the herds having troubles for a long time where the sanitation measures are systematically conducted (Н.А.Александров, 1977). Very often there is atypical reaction at such farms. This fact is explained by the author with the immunity state of the compromised herd. If this phenomenon is considered from the general biological point of view it should be taken into consideration that the host develops tolerance and the parasite develops adaptation to appropriate living conditions. After long term of antibovine tuberculosis’ measures conducted in Novosibirsc region and the analysis of epizootic situation concerning this infection we came to an analogous conclusion. We can give a great deal of examples showing that in normal terms of vital activity there are certain species of animals left to be “carriers” or they go through certain disease in latent form. In this case “the epizootic process is an uninterrupted chain series of subsequent new and new or infections of animals the organism of which is the internal environment for the parasite” (М.И.Верещагин, 1962). It is easy to notice that the un the said conditions the organism of the obligate host in the internal environment for the parasite It was already told by many facts confirming that the causative agents of some infectious diseases do not obviously influence animals in certain conditions. Many scientists pointed out this peculiarity as the condition of the causative agent survival (В.Д.Беляков, 1975; Ш.Николь, 1937; Ф.М.Бернет, 1947; К.Эндрюс, 1969). This peculiarity is rather essential. It determines the law of obligate ness in the epizootic process, the gist of which consists in the fact that every type of causative agent (parasite) in the process of evolution was adapted to the internal environment of certain species animals or human being (host) who is obligatory for parasite vital activity and its survival as a species. The parasite vital activity within the obligate host organism causes the chronic or latent form of the diseases stipulated with the state of biological balance established between them in the course of evolution. The main prognostic moment of this law should be considered to be the probability to ascertain a principal source of causative agent. For example, the African hog cholera causative agent, undoubtedly, survives in hogs. But the manifestation of this infection within European hogs is so acute that naturally the question raises: where the causative agent survives? If the relations between the parasite and its host are rather antagonistic it should be supposed that the infectious disease is very new and it is at its initial stage of its own evolutional formation or the causative agent survives in some populations being in close relationship. The answer to this question is rather quickly given by knowledge of the epizootic situation. In fact the aboriginal warted hogs of fat type proved to be destined in the South of Africa. They were carriers of the causative agent but do not have the clinical form of hog cholera or become ill only after stress influence. The epizootic situation of classic hog cholera should be regarded analogically. If to appreciate the degree of clinical form of the disease effecting European hogs, in particular, changes in manifestation of infections and epizootic process for several decades it should be assume that somewhere there are animal populations of certain species which are the carriers of causative agent but they themselves have no clinical form of the disease. On the basis of analysis of laws (regularities), peculiarities and tendencies in manifestation of some epizootic process of classical hog cholera we can assume that there are regions of constant habitat for such hogs that is the Central or South-Central Asia. It is possible to illustrate this law with one more example. It is well known that the underbred horses with typical clinical symptoms’ had slanders rather seldom. Meanwhile many of them had positive reaction to mullein and, of course, were carriers of the causative agent. Their contacts with half-bread horses, especially with high half-bred ones, as a rule, caused the latters to have the acute form of the said infection. Thus, every type of causative agents being parasites have its own or several types of hosts in whose’s populations the parasite exists. The primary cause of some infectious diseases’ propagation is the evolutionally established biocenetic connections between the parasite and its obligate host. This essential connection must blend in naturally with the theory of epizootic process and be taken into consideration during the epizootological analysis. But you should in mind that in number of cases the ways of the causative agent transmission. In their turn the said ways of transmission are determined by the agricultural and transport activity of people. Such ways were not determined by the evolution of biocenetic relations between the parasite and its host. They are secondary or accidental. Proceeding from the law of obligate ness it can assumed that animals having the acute form of disease cannot be obligate hosts for the causative agents of corresponding diseases. Accordingly, the farm animals are not the obligate host for the causative agent of anthrax.Effect of biogenetic law in the epizootic process The state of biological balance between the parasite and its obligate host is always relative. It should be considered on a historical evolutional plan. Analyzing the peculiarities of propagation of infectious disease we can assume that the manifestation of epizootic process towards the obligate hosts during different periods of the parasite and its host joint evolution is unequal. Their initial meeting was displayed with the more acute manifestation of the infectious disease. If the parasite did not kill the animal and between them were established biocenetic connections then in the process of evolution the adaptation of the parasite to corresponding environment (host organism) would have taken place, and the host and more would have developed tolerance towards the parasite vital activity. The interaction between the parasite and its host was getting near the biological balance in the course of joint evolution. The longer the joint evolution of parasites and hosts is, the less the aggressiveness of the parasite is manifested. Accordingly, in modern situations, the more ancient the infectious disease the easier it manifests itself in the organism of obligate host. Thus, in modern situation, changes in manifestation of the epizootic process of certain infectious disease among the obligate hosts are characterized by changes in its manifestation which took place in the course of joint evolution of the parasite and its host. This peculiarity should be regarded as the biogenetic law of the epizootic process. If to consider the changes in relations between the populations of causative agent and the populations of obligate hosts during one generation (in ontogeny), them according to the biogenetic law all the development stages of these relations must follow the level of manifestation of epizootic process being characteristic of relations between the parasite and its host during different periods of their joint evolution (phylogeny). This law shows that the character of disease propagation among animals being the obligate hosts is based on the duration of interactive relations between these animals and parasites in the historical evolutional plan. The duration of joint evolution of the parasite and its host determines the level of propagation of infectious disease during the different periods of epizootic development. The biogenetic law determining the development of biocenotic system “parasite – host” is rather similar to the E.Gekkel’s and Ph.Müller’s biogenetic law, according to which the individual development of a specimen (ontogeny) is determined by the peculiarities of its ancestry’s development (phylogeny). The correlation between the degrees of biological balance between a parasite and its obligate host during one generation within the certain period of phylogenetic age is confirmed with the numerous epizootic observations, pointing out the objectivity of epizootic process biogenetic law. For example, undoubtedly, cattle are the obligate host for the causative agent of bovine brucellosis. There is always an acute form of brucellosis during the propagation of causative agent among clean herds. But the acuteness of manifestation of infectious process gradually decreases and after 3 – 4 years the disease is found only through serological reactions. The latent “carrying” of brucellosis causative agent within such herds is sure to continue. Such a peculiarity of manifestation is characteristic of all the diseases when spreading among the obligate hosts (African hog cholera aboriginal hogs, equine anemia and others). It is stipulated by phylogenetically determined changes in living conditions of the causative agent within the obligate host organism.Stress effect on animals being the its hosts of the parasite as the factor facilitating aggravation of epizootic process manifestation If the balance between the parasite and its obligate host is maintained owing to stipulated by evolution adaptation of causative agent to vital activity under certain conditions of such host organism then it should be admitted that changes in these conditions would result in changes of parasite vital activity. Parasite’s living conditions within the obligate host organism can change as a result of effects of different stress environmental factors on animals. Such a mechanism, according to scientists (Н.В.Башенина, 1963), explains the periodical changes in size of rodent. One of the leading causes of periodical mass death of animals is considered to be the infectious diseases appearing among “carriers” of the causative agent after stress effects on their hosts. The latent infections as if revives, intensifies; simultaneously many carriers of microbes are ill during a short period. In such situation the virulence of causative agent is undoubtedly increased and accordingly the role of horizontal contamination (spreading) is becoming more significant. In modern conditions the weakening of farm animals after different stress effects is regarded as the decrease of organism resistance. Besides, if the animal, being the obligate host of a certain parasite, was in the state of latent infection or microbe carrying then the stress effects would have increased their aggressiveness and would have resulted in the distinct manifestation of epizootic process. This peculiarity of the epizootic process manifestation is confirmed by numerous epizootic observations. For example, the facts of cattle’s mass tuberculosis infections during the period of wet cold housing for animals having poor ration, after transportation and change of housing conditions are explained by increased aggressiveness of causative agent within the obligate host organism (“carrying”). Uncompleted and poor ration, wet and cold housing result in the essential changes of biochemical and physiological indices of the environment for parasite vital activity – Mycobacterium tuberculosis bovis. Against such a background the aggravation of tuberculosis is observed. It is experimentally proved that the transportation and changes in climatic conditions are the stress factors leading to the increase of cattle’s sensitiveness towards tuberculosis (А.О.Бокун, 1977; Н.М.Комаров, 1973). It is also true for salmonellosis (М.Тагидзе, 1978). In 2 months after the infection of guinea – pigs with sublethal dose Salmonella abortus ovis it provoked the disease using the antigen of corresponding culture. Before the inoculation of culture the agglutinin titer was 1: 10 – 1: 40. In one week after inoculation antigen it increased to 1: 320. The infection of sheep being the bacteria carriers was provoked after the inoculation of antigen. The agglutinin titer was increased from 1: 200 to 1: 800. After intensive exploitation of horses the acute aggravation equine anemia was observed. This factor could possibly influence the changes in biochemical and physiological indices. The stress effect on animals explains the outbreaks of young cattle virus respiratory diseases being observed at the farms where the housing conditions differ from those at the farm providers. In this cause the animals of farm providers were already the “carriers” of virus caused them to have the respiratory diseases at the farm. Virus should no aggressiveness in the animal’s organisms at the farm-providers since was kept the state of balance maintained with the traditional economic and veterinary hygiene conditions. At the farms conditions for cattle distinctly differed from the traditional ones. Housing of young cattle under high temperature essentially influenced gaseous interchange and blood indices and resulted in increase in the number of sickness rate due to the decrease of organism resistance (Н.М.Комаров, 1974). The epizootic role of stress effect is surely showed by the experiments (М.Тагидзе, 1978) with the animals being the carriers of the causative agent. The aggravation of development of infectious process and in connecting with the manifestation of epizootic process is stipulated with the violation of essential interconnections in the field of biocenotic relations “parasite – host”. We can give many examples when in normal conditions of housing the animal being the obligate host is only the “carrier” of causative agent being the parasite, and during changes in housing conditions leading to changes in biochemical indices of host organisms then a corresponding disease appears. This phenomenon is stipulated with the effect of stress factors. Therefore the diseases are defined as factorial. Many diseases become widespread as the result of unfavorable environmental effects (А.Л.Скоморохов, 1951). They have essential influence on the gaseous and energy interchange, clinical and physiological, biochemical and other indices. It is surely demonstrated be the experiment (Н.М.Комаров, 1973). This essential peculiarity was defined by us as the law of stress in epizootic process. Its gist consist in the fact that under the effect of environmental conditions changes in biochemical indices of obligate host organism result in the changes of parasite living conditions and they are the cause of its high aggressiveness, the aggravation of infectious process and the increase of manifestation of epizootic process. One should take into consideration the effect of this law during epizootic analysis. Thus, the intensiveness of “parasite – host” relations, as it was already mentioned, was stipulated by the adaptation of the parasite to some certain environment and by the developed tolerance of the obligate host towards the vital activity of the parasite. The change of parasite’s living conditions results in the high aggressiveness and appearance of corresponding infectious disease. Of course, it concerns the infectious diseases of animal being the obligate hosts of corresponding causative agents.The role of accidental hosts in epizootic process We can give other examples confirming the principal law of epizootic process of “parasite – host” relations, the law of obligate ness, the law of stress and biogenetic law of epizootic process. All the laws reflect the essence of parasite – host relations and generate certain objective regularities of epizootic process manifestation towards the obligate host of the parasite. Bat the objective regularities are inevitable accompanied by accidents. This peculiarity is the cause of appearance of new species, development of new processes and etc. (for example, genetic mutations). It is also typical of the epizootic process. If the evolutionally established biocenotic connections are compulsory for the parasite and its host and the organism of such hosts is the optimal environment for the vital activity of parasite, then in nature there are such species whose organism by their biochemical indices are close to those of obligate hosts. But these animals do not evolutionally adapt to the vital activity of parasite within their organisms due to lack of stable biocenotic connections between them. The accidental penetration of parasites into such hosts causes the disease to be acute, sometimes with fatal outcome. Such animals are conveniently defined as potential hosts towards the parasites. We take into consideration that in certain conditions there is a possibility to establish the biocenotic connections between them and the parasites, then in the long process of evolution the animals of such species are transformed into the obligate hosts of parasite. Under the influence of environmental mutagens, they, at some stage 0f evolution acquire the characteristics differing from the initial ones (Н.П.Дубинин, 1978). It is understood that the high disease contagiousness of animals being the potential hosts can (to a certain extent) result in the continuation of disease propagation in a horizontal way without any naturally established biocenotic connections and obligate host. But such propagation is always secondary and the modern measures successfully control it. In the majority of such situations the parasite finds itself in biological and epizootic impasse. Such a phenomenon is not desirable for it, since all the micropopulation of parasite dies together with host ruined by that parasite. Many scientists paid attention to this peculiarity during zoonosis (И.И.Ёлкин, 1973) etc. It is typical of the majority of diseases having the natural centers (Е.Н.Павловский, 1964). These principles are confirmed by numerous epizootic facts. For example, the farm animals have very heavy rabies disease, as a rule, with a fatal outcome. It is enough to remember that for the last years thousands of cattle, horses, sheep were ill with rabies. They all period from this disease and micropopulations of causative agent perish together with them. We don’t know not a case of disease propagation by those animals. Because of the absence of suitable spreading mechanism the farm animals, as a rule, do not take part in the propagation of the causative agent. In this case the life of the parasite species is not maintained by farm animals, though they suffer heavily from the meeting with the mentioned parasite. Therefore, there must exist another type of animals being the obligate host of parasite. The organism of such animals, to some extent, has a tolerance to the vital activity of rabies causative agent within it. They can have no manifestation of the disease or can have it in stress situations. It is not out of place, to repeat that wild carnivores have an acute heavy form glanders and perish with after twenty – four hours. But glanders causative agent does not survive in the organism of such species and they do not spread it. Simultaneously with the death of carnivores all the micropopulation of parasite perishes. The carnivores were infected by horses, who, being the carriers of causative agent’s microbe either had no clinical form of the diseases at all, or had the disease as a result of the law of stress effect and the biogenetic law in the epizootic process. It is as similar, acute and heavy form of different diseases resulting in, as usual, the fatal outcome not long after were typical of different animals: listerelosis – for sheep, plague – for camels, Aujeski’s disease – for hogs, leptospirosis – for young cattle. The causative agent of these diseases survives within the organism of certain species of rodent, not farm animals. Thus, the obligate hosts play the role of reservoir for causative agent; meanwhile the potential ones serve as the indicators of causative agent’s carrying among the obligate hosts. Micsomatosis of rabbits can be a convincing example. The natural reservoir for this infection causative agent is the tropical forest South-American rabbit (К.Эндрюс, 1969; Ф.Феннер и др. 1977). In normal conditions of habitat the development of this infectious process is rather harmless since it does not result in death. The domestic rabbits serve as animal indicators or, according to our definition, potential hosts for finding out of tropical forest South-American rabbit’s microbe carrying of this virus. They heavily go through disease and perish with micsomatosis. There are many such examples of contagions agent for this infection is tropical forest South-American rabbit. In normal conditions of the habitats the development of its infections process is comparatively harmless since it does not result in dealt. Domestic rabbits serve as animal indicators or according our definition, potential hosts for finding out of tropical forest South-American rabbit’s microbe carrying of this virus. They heavily go through disease and perish with micsomatosis. There is a great deal of such examples. Of course, the effect ob epizootic process proceeding among the animals being the obligate hosts of the parasite is proved to be a highly effective measure to control the diseases, for which farm animals are the potential hosts. A number of scientists (Н.Р.Дядичев, 1959) notice the fact that “strictly specific mechanism of contagious agent’s transmission naturally acting only in the environment of certain species of warm-blooded animals usually stipulates more or less strict adaptation of pathogenic microorganism to parasitic living within organisms of only given species of warm-blooded host”. If it’s true then, probably, it’s impossible to tell of about farm animals being an environment for anthrax’s causative agent since it lives there only for several twenty four hours. Farm animal’s organism is turned out to be not ready for living of parasite being anthrax’s causative agent. Then naturally, the question is the organism of which animals is the principal environment in which the parasite exists. There is not any exact answer to this question as yet. Some scientists (В.А.Краминский, 1968) leaving out of account the significance of evolutionally established biocenotic connections and natural selection of “parasite – host” relations consider the capability of anthrax’s causative agent to cause the ruminants the generalized process in ruminants and, the adaptation of this parasite to ruminants. Others (В.Я.Скляров, 1971) thick that there is no necessity of the causative agent for this infection in animals hosts since it exists in soil in the form of spores. But existing question of epizooty are not taken into consideration. The questions are the unequipollent spread of infection and clinical manifestation of infections process among different species of animals, the stability of seasonal prevalence and its unequivalence among different species of animals, etc. All this makes it possible to assume that in nature there are some warm-blooded animals species for whom the causative agent of this disease exists. The organisms of such animals are tolerance towards the vital activity of parasite being anthrax’s causative agent. And the farm animals that are accidentally found in the wag of vital activity of such parasite heavily go through disease and, as a rule, perish remaining only its potential hosts. The epizootic situation analysis of concerning this group of infections diseases among farm animals does not allow to determine their epizootic process as “a continuous chain series of following new and new infections of animals” (И.В.Давыдовский, 1956). The organism of farm animals is only temporary internal environment for the causative agent of the said infectious diseases. Between two outbreaks of these diseases among farm animals there are long intervals during which the causative agents are sure to be perished out of the animal organism. But they survive within the obligate hosts which are not farm animals when there are mentioned diseases. The objective regularities of territorial limitation, seasonal prevalence and periodical recurrence are dependence of one habitat’s sick animals on recurrent outbreaks of other habitats is not observed. The determination of the se peculiarities is destined to direct scientists to search for the obligate hosts of causative agents dwelling in place of outbreaks among the farm animals. In such cases the control of the epizootic process among wild animals (obligate hosts) will be a rather effective criterion for the forecast and preventive measures against the disease among the farm animals. That is why it is necessary to find out the obligate host of the parasite and to effect on the epizootic chain formed by in. The animals being the obligate hosts the parasite are the principal sources and reservoirs of the causative agent. During the outbreaks of some disease in acute form the farm animals are the source of their causative agent as well. The epizootic significance of such a source depends on the ways of causative agent’s transmission which, in their turn, very often depends on people’s economic activity. But these ways do not take part in the maintenance of the causative agent’s vital activity, they are accidental. That’s why the host should be regarded as potentially dangerous one. Such peculiarities must be regarded as the effect of the potentiality law in the epizootic process. Its essence consists in the fact that the parasites being the infections diseases causative agents sometimes penetrate the organism of non-obligate host in accidental way. Because of the chance causes said organism turned out to be the suitable environment for the vital activity of the parasite. The dialectical unity of enumerated laws forms the universal theory of the epizootic process. Graphic model of general epizootic process The laws on the principle of parasite host relations can be integrated into general theory of epizootic process and represented in the form of graphic model. The law of obligate ness of the epizootic process using such a model is represented by the normally getting thin spiral, showing formed by the joint evolution the change of biological balance between parasites and their hosts (fig.1).Fig.1 Evolution of epizootic process on obligate hosts of causative diseasesThe longer the joint evolution of the parasite and its host, the more distinct is the biological balance and accordingly, the parasite’s aggressiveness is decreased. This is showed by the normally getting thin graphic spiral. The effects of the law of stress (fig.2) and the biogenetic law of epizootic process (fig.3) are characterized by the comparatively short but rather considerable getting thick spiral, pointing out the considerable short violation of biological balance between the parasite and its host or the aggravation in manifestation of infectious and epizootic processes.Fig.2 The influence stress factors on manifestation of infectious and epizootic process on obligate hosts of causative diseasesFig.3 Effects of biogenic law on manifestation of infectious and epizootic process on obligate hosts of causative diseasesThe fig.4 shows the effect of the law of potentially in the epizootic process. The straight lines coming radially from the spiral points out the penetration of the causative agent into the non-obligate (potential) host. It is possible to continue their joint evolution resulting in the biological balance between this parasite and its new host and, very likely, the formation of new disease. Thus all the causative agent are parasites. The obligate hosts are specific to every type of the causative agents. The rations between the obligate host and the parasites rush to a state of biological balance, being the result of their joint evolution. The degree of such a balance manifestation depends on the duration of their joint evolution. In optimal conditions of such interrelations the host has the tolerance towards vital activity of parasite, in addition to it the host has no symptoms of disease and it a number of cases even has no reaction to the corresponding diagnostics. Both domestic animals and wild animals can be such hosts. The changes in the biochemical and physiological indices of obligate host organism result in the change of living conditions for the causative agents (parasites). Such changes are the cause for the intensification of parasite vital activity, heightened reaction of animal organism to this vital activity and manifestation of the disease is apparently accompanied by an increase in causative agent virulence, what is rather essential for further spread of disease. These natural phenomena play the role of regulators for wild animal’s population (Н.В.Башенина, 1963). At the same time because of the accidental causes the parasite can also penetrate the animals’ organisms which are not the obligate host. If the organism of such animals by its biochemical and physiological indices is close to the obligate host organism then the parasite will spread within it and display heightened aggressiveness resulting in the acute form of infectious process and the heightened intensity of epizootic process manifestation. If wild animals were the parasites obligate hosts, then during the period of effect of the law of stress or the biogenetic law in the epizootic process, the probability of infecting the domestic animals being the potential host of the parasite is distinctly increased. This peculiarity determines the objective regularities of disease spread among the animals not being the obligate hosts for the parasite. Therefore, the epizootic process of diseases concerned in animals being the obligate hosts in the role of reservoir for a causative agent can also draw non-obligate (potential) hosts in having the acute form of disease and damaging the animals. If there are some suitable conditions, the disease can spread among the potential hosts. In many cases it determines the epizootic situation. But modern antiepizootic and preventive measures make it possible quickly to block such a spread up. The disease among animals being non-obligate hosts can have wide spread but because of the absence of evolutionally established ways of a causative agent transmission, the spread will end sooner or later. But the disease can appear again if there is no control on its spread towards obligate host of parasite. The graphic representation of laws and their dialectical unification into the general theory explain the well-known peculiarities of epizootic process manifestation the natural centre (Е.Н.Павловский, 1964) and can be the model to understand the course of further studies the general theory and laws will be concretized and deepened. The theoretical elaborations must be confirmed with new facts of peculiarities and objective regularities to manifest the epizootic process of different infectious diseases. The effect of said laws is rather distinctly observed using the epizootic process’ model of horse glanders. But it is doubtful that causative agent can exist in nature only within animal organism. This is the main point of the epizootic process principal law being the law of parasite-host relations. In the process of evolution between the glanders’ causative agent and some underbred horse the state of biological balance was established ensuring the survival of parasite type. The horses within organism of which the parasite survived as a species became the obligate host of the causative agent. It is confirmed with the epizootic studies. 87% of all found out in the USSR for 1925-1926 horses having glanders were the animals with the chronic form of the latent glanders reacting only to mallein without clinical symptoms of the disease (С.Н.Вышелесский, 1948). This peculiarity is stipulated by the effect of the law of obligate ness in the epizootic process. The clinical manifestation of glanders was mainly observe during the initial period if the causative agents penetration into the favorable farms or horse herds, among famished horses or horses exposed to high exploitation. Cultural well-bread horses had the more acute from of disease since their organism’s biochemical indices somewhat from those of the horses within which the glanders causative agent survived in the process of evolution. These peculiarities are explained by effect of the law of stress and the biogenetic law of epizootic process. At the same time it is known that lions, tigers, panthers and other animals while eating meat of the horses having glanders die after 2 – 5 days. The micropopulations of causative agent perish together with them. Those animals were going through disease, thus facilitating the disease propagation to a certain extent, but this fact never determined the epizootic situation. This peculiarity is explained by the effect of the law of potentiality. Unfortunately, lately there were only few attempts to determine the obligate hosts in the epizootic process of different infectious diseases and from this point of view to develop the control measures. But now there are grounds to consider that the cattle are the obligate host for the causative agent of bovine tuberculosis, horses are the obligate host for the causative agent of equine anemia. Farm animals are the potential hosts for the causative agent of anthrax, rabies, leptospirosis, listeriosis, Aujeski’s disease and a number of other diseases. The manifestation of infectious diseases towards the potential host is the indicator of latent centre of this disease in the obligate host within given area. If the control of former is successful then the latter remains very stable even if the domestic animals are not hosts. Thus, the general epizootic process us the evolTable of contents^ Theory of the epizootic process Main laws and categories of the epizootic process Grounds for necessity of theoretical developments in epizootology ………………. 1 Parasite – host nature of the epizootic process ……………………………………. 6 Obligate ness of animal species for causative agent ………………………………. 7 Effect of biogenetic law in the epizootic process ………………………………… 12 Stress effect on animals being the its hosts of the parasite as the factor facilitations aggravation of epizootic process manifestation ……….…………… 13 The role of accidental hosts in epizootic process ………………………………